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Updated: May 29, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

Triplet pregnancy with partial hydatiform mole.

M Siva Sundari¹, Preet Agarwal, Jayanthi Mohan

¹Department of Obstetrics and Gynaecology, Sri Ramachandra University, Chennai 600116.

Journal of the Indian Medical Association

|September 6, 2011

Summary

This case report details an extremely rare triplet pregnancy complicated by a partial hydatidiform mole. Despite severe pre-eclampsia, the pregnancy progressed, resulting in live birth and a favorable maternal outcome.

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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

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Published on: June 27, 2025

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Gynecologic Oncology

Background:

Triplet pregnancies are high-risk obstetric events.
Gestational trophoblastic disease, including hydatidiform mole, requires careful monitoring.
Coexistence of multiple gestation and molar pregnancy is exceptionally rare.

Observation:

A 26-year-old primigravida presented at 32 weeks gestation with severe pre-eclampsia and a triplet pregnancy.
Ultrasound revealed discordant twins and abnormal Doppler studies.
Emergency Cesarean section was performed, with placental examination showing molar changes confirmed by histopathology.

Findings:

The patient received methotrexate for rising beta-human chorionic gonadotropin (beta-hCG) levels post-delivery.
Both infants survived and are healthy three months postpartum.
Maternal beta-hCG levels normalized after treatment.

Implications:

This case highlights the possibility of successful pregnancy continuation in rare scenarios of coexisting mole and multiple gestation.
Early detection and multidisciplinary management are crucial for optimizing maternal and fetal outcomes.
Further research into the management of such complex pregnancies is warranted.