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Microfabricated Platforms for Mechanically Dynamic Cell Culture

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Microplates with adaptive surfaces.

Meshude Akbulut¹, Dhana Lakshmi, Michael J Whitcombe

¹Hacettepe University , Chemistry Department, Polymer Chemistry Division, Beytepe, Ankara, Turkey.

ACS Combinatorial Science

|September 6, 2011

Summary

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This study introduces a novel method to modify microplate surfaces with poly(N-phenylethylene diamine methacrylamide) (poly-NPEDMA), enabling photochemical grafting of functional polymers for high-throughput screening applications.

Area of Science:

Materials Science
Polymer Chemistry
Surface Modification

Background:

Polystyrene microtiter plates (microplates) are widely used in biological and chemical screening.
Surface modification of microplates is crucial for enhancing assay performance and enabling new applications.
Existing methods may lack versatility or efficiency for creating diverse functional surfaces.

Purpose of the Study:

To develop a versatile method for modifying microplate well surfaces.
To enable photochemical grafting of various functional polymers onto modified microplates.
To demonstrate the utility of these modified microplates in high-throughput screening.

Main Methods:

Chemical grafting of poly(N-phenylethylene diamine methacrylamide) (poly-NPEDMA) onto polystyrene microplates.

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Activation of pendant methacrylamide double bonds via UV irradiation in the presence of an iniferter.

Photochemical grafting of acrylate and methacrylate polymers with diverse functionalities.

Main Results:

Uniform coatings of poly-NPEDMA were successfully prepared on microplate surfaces.
A small library of functional polymers was grafted onto the microplate wells.
The modified microplates demonstrated feasibility for screening affinities to small molecules (atrazine, dyes) and proteins (BSA).

Conclusions:

The developed method offers a versatile, reproducible, and cost-effective approach for surface modification of microplates.
This technology is suitable for creating functional polymer libraries for high-throughput screening in materials research.
The method facilitates the generation of tailored surfaces for specific molecular recognition applications.