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Generalized pustular eruptions due to terbinafine
Gunseli Ozturk1, Bengu Gerceker Turk, Nezih Karaca
1Medical Faculty, Department of Dermatology, Ege University, Bornova, Izmir, Turkey.
Cutaneous and Ocular Toxicology
|September 6, 2011
Summary
Terbinafine, an antifungal drug, can rarely cause severe skin reactions. This report details three cases of generalized pustular eruptions, including acute generalized exanthematous pustulosis and drug-induced pustular psoriasis, linked to terbinafine use.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Terbinafine is a common antifungal medication.
- Cutaneous side effects occur in 2.7% of users.
- Severe adverse cutaneous reactions are rare but documented.
Observation:
- This report presents three cases of terbinafine-induced generalized pustular eruptions.
- Two cases involved acute generalized exanthematous pustulosis (AGEP).
- One case involved generalized pustular psoriasis (GPP).
Findings:
- Terbinafine can trigger uncommon but severe skin reactions like AGEP and GPP.
- These pustular eruptions represent significant adverse events associated with terbinafine therapy.
- The presented cases highlight the spectrum of severe cutaneous reactions to terbinafine.
Implications:
- Clinicians should be aware of the potential for terbinafine to induce generalized pustular eruptions.
- Early recognition and discontinuation of terbinafine are crucial for managing these severe reactions.
- Further research may elucidate the mechanisms behind terbinafine-induced pustular conditions.
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