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Related Concept Videos

Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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Overview of Lipid Metabolism

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Lipolysis: The Breakdown of Lipids:
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Sulfur Assimilation01:20

Sulfur Assimilation

Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...
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Biosynthesis of Lipids

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Smooth Endoplasmic Reticulum

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Related Experiment Video

Updated: May 29, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Nuclear sphingolipid metabolism.

Natasha C Lucki1, Marion B Sewer

  • 1School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Annual Review of Physiology
|September 6, 2011
PubMed
Summary

Nuclear sphingolipids regulate key cellular processes like DNA repair and transcription. This review details how these lipids function within the nucleus and influence gene expression and cell fate.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Nuclear lipid metabolism is crucial for transcription, splicing, and DNA repair.
  • Sphingolipids are increasingly recognized for their roles in nuclear functions.
  • Specific sphingolipid species reside in subnuclear domains, impacting nuclear processes.

Purpose of the Study:

  • To review the factors controlling nuclear sphingolipid metabolism.
  • To summarize the diverse roles of nuclear sphingolipids in cellular functions.
  • To highlight the regulatory and structural functions of sphingolipids within the nucleus.

Main Methods:

  • Literature review of studies on nuclear lipid metabolism.
  • Analysis of research on sphingolipid localization and function within the nucleus.

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Analysis of SCAP N-glycosylation and Trafficking in Human Cells

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Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species
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Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species

Published on: May 7, 2018

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Last Updated: May 29, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
11:27

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

Published on: November 8, 2016

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species
08:53

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species

Published on: May 7, 2018

  • Synthesis of findings on sphingolipid species and their nuclear roles.

    • Main Results:

    • Sphingomyelin is abundant in the nucleus, affecting chromatin assembly and the nuclear matrix.
    • Sphingosine-1-phosphate and sphingosine modulate histone acetylation and act as ligands.
    • Nuclear ceramide is linked to apoptosis, and ganglioside GM1 impacts calcium homeostasis.

    Conclusions:

    • Nuclear sphingolipids are vital regulators of fundamental nuclear processes.
    • Understanding nuclear sphingolipid metabolism offers insights into gene regulation and cell signaling.
    • Further research into nuclear sphingolipid functions is warranted for therapeutic potential.