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[Leprosy. Pathogenesis--classification--diagnosis--treatment].

P Stingl

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |March 1, 1990
    PubMed
    Summary

    Leprosy, a chronic Mycobacterium leprae infection, affects nerves and skin, with outcomes varying by immune response. Effective chemotherapy now cures leprosy, preventing severe disabilities.

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    Area of Science:

    • Infectious Diseases
    • Immunology
    • Dermatology

    Context:

    • Leprosy, or hanseniasis, is a chronic infectious disease.
    • Caused by Mycobacterium leprae (M. leprae) infection.
    • Primarily affects peripheral nerves and skin, but can impact any organ.

    Purpose:

    • To describe the clinical spectrum of leprosy.
    • To differentiate between multibacillary and paucibacillary forms.
    • To highlight the role of host immune response in disease presentation.

    Summary:

    • Leprosy presents diverse clinical features influenced by the host's immune response.
    • Classified into multibacillary (lepromatous, borderline-lepromatous, borderline-borderline) and paucibacillary (tuberculoid, borderline-tuberculoid) forms.
    • Clinical and histological findings correlate with immune status.

    Impact:

    • Effective chemotherapy is available for leprosy treatment.
    • Leprosy is now a curable disease.
    • Preventable disabilities associated with leprosy are a significant public health achievement.

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