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Related Concept Videos

NMR Spectroscopy: Spin–Spin Coupling01:08

NMR Spectroscopy: Spin–Spin Coupling

The spin state of an NMR-active nucleus can have a slight effect on its immediate electronic environment. This effect propagates through the intervening bonds and affects the electronic environments of NMR-active nuclei up to three bonds away; occasionally, even farther. This phenomenon is called spin–spin coupling or J-coupling. Coupling interactions are mutual and result in small changes in the absorption frequencies of both nuclei involved. While nuclei of the same element are involved in...
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
¹H NMR: Long-Range Coupling01:27

¹H NMR: Long-Range Coupling

The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are slanted or...

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Related Experiment Video

Updated: May 29, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Recoupling in solid state NMR using γ prepared states and phase matching.

James Lin1, R G Griffin, Navin Khaneja

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|September 6, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces novel two-dimensional solid-state NMR techniques using gamma-prepared states for enhanced sensitivity and resolution. These methods improve spectral quality by suppressing diagonal peaks in 2D NMR spectra.

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Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing
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Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing

Published on: December 3, 2013

Related Experiment Videos

Last Updated: May 29, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing
15:58

Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing

Published on: December 3, 2013

Area of Science:

  • Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy
  • Advanced NMR methodology

Background:

  • Two-dimensional (2D) NMR experiments are crucial for complex molecule analysis.
  • Sensitivity and resolution are key challenges in solid-state NMR.

Purpose of the Study:

  • To develop novel 2D solid-state NMR experiments for improved sensitivity and resolution.
  • To utilize gamma-prepared states for chemical shift encoding.
  • To design pulse sequences for suppressing diagonal peaks in 2D NMR spectra.

Main Methods:

  • Implementation of 2D solid-state NMR experiments using dephased antiphase coherence (gamma preparation).
  • Refocusing of gamma-prepared states into inphase coherence using recoupling elements.
  • Design and application of new phase-modulated heteronuclear and homonuclear recoupling pulse sequences.

Main Results:

  • Achieved sensitivity enhancement in 2D NMR experiments via quadrature detection.
  • Demonstrated manipulation of gamma-prepared states by controlling delays in recoupling periods.
  • Successfully suppressed diagonal peaks in 2D spectra, leading to improved resolution.

Conclusions:

  • The described gamma-preparation method enhances sensitivity and resolution in 2D solid-state NMR.
  • Novel recoupling pulse sequences simplify the implementation of these advanced NMR techniques.
  • The approach offers a powerful tool for spectral quality improvement in solid-state NMR analysis.