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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture
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A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

Published on: March 17, 2023

Galectin-3 and the skin.

Larissa Larsen1, Huan-Yuan Chen, Jun Saegusa

  • 1Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, CA 95816, United States.

Journal of Dermatological Science
|September 6, 2011
PubMed
Summary
This summary is machine-generated.

Galectin-3, highly expressed in skin cells, influences inflammatory skin diseases like atopic dermatitis and contact hypersensitivity. It also plays a role in skin cancer development and progression, suggesting it as a therapeutic target.

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Area of Science:

  • Dermatology
  • Immunology
  • Oncology

Background:

  • Galectin-3 is expressed in epithelial cells, including keratinocytes.
  • It modulates immune cell functions relevant to skin diseases.
  • Galectin-3's role in skin cancer is complex, with varied expression in different tumor types.

Purpose of the Study:

  • To review the role of galectin-3 in inflammatory skin diseases.
  • To investigate galectin-3's involvement in skin tumor progression and development.
  • To explore galectin-3 as a potential therapeutic target for skin conditions.

Main Methods:

  • Literature review of galectin-3's functions in skin.
  • Analysis of galectin-3 expression in various skin conditions.
  • Discussion of signaling pathways regulated by galectin-3.

Main Results:

  • Galectin-3 promotes Th2 immune responses in atopic dermatitis.
  • It regulates antigen-presenting cell migration in contact hypersensitivity.
  • Galectin-3 influences keratinocyte apoptosis via ERK and AKT pathways.
  • Expression patterns differ between melanoma and non-melanoma skin cancers.

Conclusions:

  • Galectin-3 is implicated in the pathogenesis of inflammatory skin diseases.
  • It plays a significant role in skin tumor growth, apoptosis, motility, invasion, and metastasis.
  • Galectin-3 represents a promising therapeutic target for diverse skin diseases.