Related Experiment Video
Updated: May 29, 2026

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
Poly (N-isopropylacrylamide)/poly (ethylene oxide) blend nanofibrous scaffolds: thermo-responsive carrier for
Fei Song1, Xiu-Li Wang, Yu-Zhong Wang
1Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, China. songfei520@gmail.com
Abstract:
A facile electrospinning method has been utilized to fabricate poly (N-isopropylacrylamide) (PNIPAM)/poly (ethylene oxide) (PEO) blend nanofibers having the mean fiber diameters from approximately 250 to 380 nm. Scanning electron microscopy (SEM) images showed that the morphology and diameter distribution of the nanofibrous scaffolds can be easily modulated by changing the weight ratio of PNIPAM/PEO in electrospinning solution. X-ray diffraction (XRD) and thermogravimetric analysis (TGA) demonstrated that there were interactions between the molecules of PNIPAM and PEO. Vitamin B12 was chosen as a hydrophilic model drug for in situ encapsulation in PNIPAM/PEO blend nanofibrous scaffolds. The rate of drug release can be controlled by adjusting the weight ratio of PNIPAM/PEO, the temperature of release medium and the drug loading amount. It is suggested that the blend nanofibrous scaffold could be used as a new thermo-responsive matrix for the entrapment and controlled release of drugs.
More Related Videos
09:09Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
Published on: February 27, 2016
09:11Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Stimuli-Activated