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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

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Pneumonia I: Introduction

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Related Experiment Video

Updated: May 29, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Medically indicated--iatrogenic prematurity.

Amy E Wong1, William A Grobman

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

Clinics in Perinatology
|September 6, 2011
PubMed
Summary
This summary is machine-generated.

Preterm delivery may be necessary for pregnancy complications. Evidence for optimal timing is often limited, requiring individualized risk assessment for mother and infant.

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Maternal-Fetal Medicine

Background:

  • Pregnancy complications sometimes necessitate delivery before full term.
  • Preterm delivery before 37 weeks of gestation is a significant clinical consideration.

Purpose of the Study:

  • To review common medical indications for preterm delivery.
  • To evaluate the evidence supporting delivery before 37 weeks of gestation.

Main Methods:

  • Literature review of medical indications for preterm delivery.
  • Analysis of evidence supporting delivery before 37 weeks of gestation.

Main Results:

  • Common medical indications for preterm delivery were identified.
  • Evidence supporting delivery before 37 weeks is limited for many conditions.
  • Management decisions often rely on expert opinion due to data scarcity.

Conclusions:

  • Individualized assessment is crucial to balance risks of continued pregnancy against risks of prematurity.
  • Weighing maternal and fetal risks against risks of prematurity and associated morbidities is essential.