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Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study
Claire E Hastie1, Gordon C S Smith, Daniel F Mackay
1British Heart Foundation Cardiovascular Research Center, University of Glasgow, Glasgow, Scotland, United Kingdom.
Objective:
We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery.
Study Design:
This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy resulting in a singleton, liveborn infant delivered between 24-43 weeks' gestation. Linear regression analysis was used to examine the association between preterm delivery and subsequent CRP concentration.
Results:
The difference in CRP between women who delivered term and preterm was nonsignificant on univariate analysis (beta coefficient 0.04, P = .18) but was statistically significant following adjustment for potential confounders (beta coefficient 0.05, P < .05). On subgroup analysis the association was specific to women who had had indicated preterm delivery (unadjusted beta coefficient 0.09, P < .01; adjusted beta coefficient 0.09, P < .01).
Conclusion:
Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.
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