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[Glioblastoma in the elderly].

¹Service de neurologie Mazarin, hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, Paris, France. jean-yves.delattre@psl.aphp.fr

Revue Neurologique

|September 6, 2011

Summary

Malignant glioma incidence is rising in older adults. Research is exploring radiotherapy and temozolomide chemotherapy, with surgical resection

Area of Science:

Neuro-oncology
Geriatric Medicine
Clinical Oncology

Background:

Increasing incidence of malignant gliomas in aging populations of industrialized nations.
Clinical research is focusing on this demographic due to rising rates.
Existing treatments show promise, necessitating further investigation.

Purpose of the Study:

To evaluate the efficacy of radiotherapy and temozolomide chemotherapy in elderly patients with malignant gliomas.
To assess the role of surgical resection in this fragile population.
To identify factors influencing treatment decisions, including functional status, quality of life, and comorbidities.

Main Methods:

Prospective studies evaluating radiotherapy and temozolomide.
Phase III study assessing combined concomitant and adjuvant chemotherapy with radiotherapy.

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Analysis of initial functional status, quality of life, and comorbidities.

Main Results:

Preliminary results from prospective studies indicate the value of radiotherapy and temozolomide.
The efficacy of combined chemotherapy and radiotherapy is under evaluation in a phase III trial.
Surgical resection's benefit requires formal demonstration in this specific population.

Conclusions:

Radiotherapy and temozolomide show promise for malignant gliomas in the elderly.
Further research is needed to confirm the benefits of surgical resection in this group.
Personalized treatment approaches considering patient-specific factors are crucial.