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Related Concept Videos

Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...

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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

Coupling mitochondrial and cell division.

Koji Yamano, Richard J Youle

    Nature Cell Biology
    |September 6, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Mitochondria fragment during cell division. Researchers found that cyclin B-CDK1 and Aurora A kinases work with RALA and RALBP1 to control mitochondrial fission by phosphorylating DRP1.

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    A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy

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    A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy

    Published on: July 20, 2012

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Genetics

    Background:

    • Mitochondrial dynamics are crucial for cell division, requiring the fragmentation of the mitochondrial network.
    • Proper segregation of mitochondria ensures cellular health in daughter cells.

    Discussion:

    • The study identifies a novel signaling pathway involving mitotic kinases and small GTPases in mitochondrial fission.
    • Cyclin B-CDK1 and Aurora A kinases collaborate with RALA and RALBP1 to regulate mitochondrial morphology during mitosis.
    • This cooperation leads to the phosphorylation of Dynamin-related protein 1 (DRP1), a key mediator of mitochondrial fission.

    Key Insights:

    • A coordinated mechanism involving cyclin B-CDK1, Aurora A, RALA, and RALBP1 governs mitochondrial fission.
    • DRP1 phosphorylation is a critical downstream event regulated by this complex.
    • This pathway is essential for the accurate segregation of mitochondria during mitosis.

    Outlook:

    • Further research can explore the precise molecular interactions within this pathway.
    • Understanding this process may offer new therapeutic targets for diseases associated with mitochondrial dysfunction.
    • Investigating potential upstream regulators of RALA and RALBP1 in this context is warranted.