Related Experiment Video
Updated: May 29, 2026
08:00
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Acute visual loss induced by dexamethasone during neoadjuvant docetaxol
D L Gregory1, C D Jones, E R E Denton
1Department of Oncology, Addenbrookes Hospital, Cambridge, UK.
Clinical Medicine. Oncology
|September 6, 2011
Summary
A patient experienced sudden vision loss from central serous retinopathy due to steroid use during breast cancer chemotherapy. Reducing steroid dosage allowed vision recovery and chemotherapy completion.
Area of Science:
- Ophthalmology
- Oncology
- Pharmacology
Background:
- Central serous retinopathy (CSR) is an ocular condition often associated with corticosteroid use.
- The link between CSR and solid tumor management, particularly with chemotherapy regimens, is not well-documented.
Observation:
- A female patient undergoing second-line neoadjuvant chemotherapy for breast cancer developed acute visual loss.
- The visual disturbance was diagnosed as central serous retinopathy, attributed to steroid premedication for docetaxel administration.
Findings:
- This case represents the first reported instance of central serous retinopathy associated with chemotherapy for solid tumors.
- Management involved reducing the steroid dose and duration, which led to the recovery of the patient's visual acuity.
Implications:
- Steroid-induced central serous retinopathy is a potential complication in cancer patients receiving chemotherapy.
- Ophthalmologists and oncologists should be aware of this association for timely diagnosis and management.
- Adjusting steroid regimens can allow for the successful completion of oncological treatments while preserving visual function.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:19Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...