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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
The Placebo Effect01:54

The Placebo Effect

The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...

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Related Experiment Video

Updated: May 29, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Medicines adherence--evidence for any intervention is disappointing.

Linda J M Bryant1

  • 1Department of General Practice and Primary Health Care, School of Population Health, The University of Auckland, PB 92019, Auckland, 1142, New Zealand. linda@cpsl.biz

Journal of Primary Health Care
|September 6, 2011
PubMed
Summary

Improving medication adherence is crucial, but interventions often yield disappointing results. Enhanced research is needed to ensure costly adherence programs are evidence-based and effective.

Related Experiment Videos

Last Updated: May 29, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Health Services Research
  • Pharmaceutical Sciences
  • Clinical Outcomes Research

Background:

  • Decades of research have focused on interventions to enhance medication adherence.
  • Despite these efforts, improvements in adherence and clinical outcomes have been suboptimal.
  • Existing studies often lack the quality and consistency needed to draw firm conclusions.

Purpose of the Study:

  • To critically evaluate the effectiveness of interventions aimed at improving medication adherence.
  • To identify gaps in current research regarding adherence interventions.
  • To inform future healthcare funding decisions for adherence programs.

Main Methods:

  • Systematic review and critical appraisal of existing literature on medication adherence interventions.
  • Analysis of study heterogeneity, intervention definition, and outcome measures.
  • Assessment of the resource intensity and cost-effectiveness of interventions.

Main Results:

  • Interventions for medication adherence have not consistently led to significant improvements in adherence or clinical outcomes.
  • Studies are characterized by heterogeneity, poor quality, and poorly defined interventions (e.g., 'educational' interventions lack specific content).
  • Many interventions appear resource-intensive, with a lack of cost-effectiveness data.

Conclusions:

  • Current evidence does not strongly support the effectiveness of many medication adherence interventions.
  • Further high-quality research is essential before significant healthcare resources are invested in labor-intensive adherence programs.
  • Future research should focus on well-defined, evidence-based interventions with clear outcome measures.