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Related Experiment Video

Updated: May 29, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Designed glucose-responsive microgels with selective shrinking behavior.

Christophe Ancla¹, Véronique Lapeyre, Isabelle Gosse

¹Institut des Sciences Moléculaires, ENSCBP, Université Bordeaux, 16 Av. Pey Berland, 33607 Pessac Cedex, France.

Langmuir : the ACS Journal of Surfaces and Colloids

|September 7, 2011

Summary

Researchers developed glucose-responsive microgels that can swell or shrink based on chemical composition, offering dual mechanisms for glucose sensing and drug delivery. These smart materials provide tunable responses for advanced applications.

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Area of Science:

Polymer Chemistry
Biomaterials Science
Nanotechnology

Background:

Glucose-responsive materials are crucial for advanced diagnostics and therapeutics.
Phenylboronic acid (PBA) derivatives are widely explored for glucose recognition.
Controlling microgel volume changes is key for targeted drug delivery and sensing.

Purpose of the Study:

To synthesize and characterize glucose-responsive microgels with tunable swelling/shrinking behaviors.
To investigate two distinct mechanisms of glucose recognition by microgels.
To establish design principles for controlling microgel response for specific applications.

Main Methods:

Synthesis of N-alkylacrylamide-based microgels incorporating PBA.
Investigating microgel volume changes in response to varying glucose concentrations.
Modifying microgel composition (monomers, cross-linkers, pH) to control response.

Main Results:

Microgels demonstrated either swelling or shrinking in response to glucose, depending on chemical structure.
Swelling occurs via single boronate binding, enabling diffusion-based drug release.
Shrinkage results from dual boronate binding, forming cross-links, suitable for sensors and valves.
Compositional control allows for glucose-responsive microgels operating under physiological conditions.

Conclusions:

Rational design of microgel network allows for predictable control over swelling or shrinking behavior.
These dual-responsive microgels are promising for selective glucose sensing and intelligent drug delivery systems.
The study provides general rules for tailoring glucose-responsive microgels for specific biomedical applications.