Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Pulmonary Function Tests

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pre and post operative occupational therapy for a toe to hand transplantation.

Occupational therapy in health care·2013

Same author

University of Massachusetts Medical School.

The New England journal of medicine·2011

Same author

Renal effects of protein-deficient vegetable diets; a functional and histological study.

British journal of experimental pathology·2010

Same author

The effect of neurohypophysial extracts on the water balance of lower vertebrates.

Biological reviews of the Cambridge Philosophical Society·2010

Same author

The renal action of posterior pituitary extract and its fractions as analysed by clearance experiments on rats.

The Journal of physiology·2010

Same author

[Faecothorax].

Zentralblatt fur Chirurgie·2010

Search research articles

Related Experiment Video

Updated: May 29, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized ¹²⁹Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Functional inhomogeneities in interstitial lung disease, assessed using (16)o(18)o.

H Heller¹, M Könen, A Overlack

¹a Department of Physiology , University of Bonn , Germany.

Isotopes in Environmental and Health Studies

|September 7, 2011

Summary

Interstitial lung disease (ILD) impairs oxygen transfer. Reduced overall fractionation factor (α(0)) in ILD patients suggests functional inhomogeneities, not diffusion limitation, affect pulmonary gas exchange.

More Related Videos

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in ¹⁸F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Related Experiment Videos

Last Updated: May 29, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized ¹²⁹Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in ¹⁸F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Area of Science:

Pulmonary Physiology
Respiratory Medicine
Gas Exchange

Background:

Interstitial lung disease (ILD) is characterized by impaired pulmonary function.
Understanding the mechanisms of impaired oxygen transfer in ILD is crucial for patient management.

Purpose of the Study:

To investigate the roles of diffusion limitation and functional inhomogeneities in impaired pulmonary oxygen (O(2)) transfer in ILD.
To differentiate between diffusion limitation and inhomogeneity as causes of O(2) transfer impairment.

Main Methods:

Respiratory mass spectrometry was used to analyze (16)O(18)O/(16)O(2) ratios in expiratory gas from 6 ILD patients and 6 healthy controls at rest.
The overall fractionation factor of respiration (α(0)) was calculated to assess O(2) transport.

Main Results:

The overall fractionation factor (α(0)) was significantly reduced in ILD patients (1.0065±3.10(-4)) compared to healthy subjects (1.0071±7.10(-4), P <0.05).
This reduction suggests that diffusion limitation is not the primary cause of impaired O(2) transfer in this ILD cohort.

Conclusions:

Findings point away from diffusion limitation as the main contributor to impaired O(2) transfer in ILD.
A two-compartment model suggests that unequal distribution of diffusion and convective O(2) transport underlies pulmonary gas exchange abnormalities in ILD patients.