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Related Concept Videos

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Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
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Related Experiment Video

Updated: May 29, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
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BPD: old and new problems.

Fabio Mosca1, Mariarosa Colnaghi, Monica Fumagalli

  • 1NICU, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, Italy. fabio.mosca@mangiagalli.it

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|September 7, 2011
PubMed
Summary
This summary is machine-generated.

Bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants, has evolved. Modern BPD presents milder but requires prolonged respiratory support due to inflammation and developmental issues.

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Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Respiratory Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a primary complication of preterm birth and the most common chronic respiratory disease in infants.
  • Advances in perinatal care have shifted BPD's clinical presentation from severe to a milder form, characterized by reduced respiratory distress but prolonged ventilator support needs.
  • Histological differences exist between "old" and "new" BPD, with the latter showing reduced alveolar development, airway injury, inflammation, and fibrosis, suggesting a developmental disorder.

Purpose of the Study:

  • To describe the evolving clinical and histological characteristics of bronchopulmonary dysplasia (BPD) in preterm infants.
  • To explore the multifactorial pathogenesis of BPD, including mechanical ventilation injury and inflammatory processes.
  • To identify potential strategies for reducing BPD incidence and severity.

Main Methods:

  • Review of clinical data and histological findings in infants with BPD.
  • Analysis of factors contributing to BPD development, including prematurity, mechanical ventilation (barotrauma, volutrauma), oxidant injury, and inflammatory mediators.
  • Examination of the role of inflammatory and anti-inflammatory mechanisms in BPD pathogenesis.

Main Results:

  • The "new" BPD form is milder clinically but characterized by impaired alveolar development and airway inflammation/fibrosis.
  • BPD development is multifactorial, involving immature lung tissue, mechanical ventilation-induced injury, and an imbalance favoring proinflammatory mechanisms.
  • A persistent imbalance favoring proinflammatory over anti-inflammatory responses is implicated in BPD development.

Conclusions:

  • Reducing injury from respiratory support interventions may decrease the incidence and severity of BPD.
  • Understanding the shift towards a "new" BPD form highlights its nature as a developmental disorder.
  • Targeting inflammatory pathways and minimizing ventilator-induced lung injury are crucial for managing and preventing BPD.