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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: May 29, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Age as prognostic factor in patients with osteosarcoma.

Melanie M Hagleitner1, Peter M Hoogerbrugge, Winette T A van der Graaf

  • 1Department of Pediatric Hematology and Oncology, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, The Netherlands. MM.Hagleitner@cukz.umcn.nl

Bone
|September 7, 2011
PubMed
Summary

Younger patients diagnosed with osteosarcoma have a significantly better prognosis. This retrospective study found survival rates decreased with increasing age at diagnosis, highlighting age as a key prognostic factor.

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Last Updated: May 29, 2026

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Area of Science:

  • Orthopedics
  • Oncology
  • Pediatric Oncology

Background:

  • Age at diagnosis is a known prognostic factor in malignancies, but its role in osteosarcoma is debated.
  • Understanding age-specific outcomes is crucial for tailoring treatment strategies in osteosarcoma.

Purpose of the Study:

  • To investigate the prognostic significance of age at diagnosis in de-novo osteosarcoma.
  • To evaluate age-specific survival rates and identify factors influencing outcomes.

Main Methods:

  • Retrospective study of 102 de-novo osteosarcoma patients.
  • Patients categorized into three age groups: ≤14, 15-19, and 20-40 years.
  • Comparison of outcomes, including 5-year overall survival rate (OSR), tumor stage, size, and histological response.

Main Results:

  • Overall 5-year OSR was 53.5%.
  • Survival rates were significantly higher in younger patients (≤14 years: 70.6%) compared to older groups (15-19 years: 52.5%; 20-40 years: 33.3%; p=0.01).
  • Older patients presented with higher stage disease, while younger patients had larger tumors but better histological response.

Conclusions:

  • Younger age at diagnosis is associated with a significantly better outcome in osteosarcoma patients.
  • Age impacts survival, tumor stage, size, and treatment response, underscoring its prognostic value.