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A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
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Published on: September 19, 2016

Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative

Zuzana Motovska, Denisa Odvodyova, Michal Karpisek

    International Journal of Cardiology
    |September 7, 2011
    PubMed
    Abstract

    No abstract available in PubMed .

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    Formation of the Platelet Plug01:22

    Formation of the Platelet Plug

    The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
    As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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