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Updated: May 29, 2026
09:35
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
[Granulomatous meningitis, crescentic glomerulonephritis and vasculitis]
Ana Ludueña1, Enrique Dorado, Judith Sarano
1Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Buenos Aires, Argentina. ana_luduena@hotmail.com
Medicina
|September 7, 2011
Summary
Wegener granulomatosis can affect the meninges, presenting as meningitis. Early diagnosis and aggressive immunosuppressive treatment led to sustained remission in a patient with this rare manifestation.
Area of Science:
- Neurology
- Rheumatology
- Nephrology
Background:
- Wegener's granulomatosis (WG) is a rare autoimmune disease characterized by granulomatous inflammation.
- Meningeal involvement in WG is infrequent but can cause significant neurological symptoms.
Observation:
- A 57-year-old male with WG presented with asymptomatic granulomatous meningitis.
- The patient also had upper respiratory tract, ear, and orbit involvement.
- He subsequently developed ANCA-positive multiple mononeuritis and crescentic glomerulonephritis.
Findings:
- Diagnostic confirmation relied on positive ANCA tests and evidence of systemic disease.
- The patient received aggressive immunosuppressive therapy, including cyclophosphamide and high-dose corticosteroids.
- Clinical remission was achieved with residual hearing loss and renal impairment.
Implications:
- This case highlights the importance of considering meningeal involvement in WG.
- Prompt and aggressive treatment is crucial for managing this rare presentation.
- Understanding WG's diverse manifestations aids in timely diagnosis and management.
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