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Related Concept Videos

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Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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Controller medication use and sleep problems in pediatric asthma: a longitudinal case-crossover analysis.

Michelle M Garrison1, Paula Lozano, Dimitri A Christakis

  • 1Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, WA 98145, USA. michelle.garrison@seattlechildrens.org

Archives of Pediatrics & Adolescent Medicine
|September 7, 2011
PubMed
Summary

Asthma controller medications improve sleep in children. Leukotriene inhibitors may be particularly effective for reducing sleep problems in pediatric asthma patients.

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Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Pharmacology

Background:

  • Sleep problems are common in children with asthma.
  • Asthma controller medications are crucial for managing the condition.
  • The impact of controller medication use and adherence on sleep quality in pediatric asthma patients requires further investigation.

Purpose of the Study:

  • To investigate the effect of asthma controller medication use, choice, and adherence on sleep disturbances in children with asthma.
  • To determine if specific types of controller medications offer greater sleep benefits.

Main Methods:

  • A case-crossover analysis was conducted using survey data from a randomized trial.
  • Parental reports on controller medication use (type, adherence) and sleep problems (difficulty falling asleep, daytime sleepiness) were collected at baseline, 6 months, and 1 year.
  • The study included 482 children aged 2 to 10 years with asthma.

Main Results:

  • Controller medication use was associated with a reduced risk of difficulty falling asleep and daytime sleepiness in children with asthma.
  • Leukotriene inhibitors showed a significant association with decreased odds of sleep onset problems.
  • While nonadherent use showed a trend, daily controller use demonstrated a statistically significant reduction in sleep problems.

Conclusions:

  • Asthma controller medications are effective in mitigating sleep problems in children with asthma.
  • Leukotriene inhibitors may offer particular benefits for improving sleep in this population.
  • Adherence to controller medications is important for optimal sleep outcomes in pediatric asthma.