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Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Insulin Formulations: Types and Delivery01:27

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Dosage Regimens: Designs and Approaches01:28

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Improving IV Insulin Administration in a Community Hospital
12:08

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Published on: June 11, 2012

Development of a web-based decision support system for insulin self-titration.

A C R Simon1, F Holleman, J B Hoekstra

  • 1Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.

Studies in Health Technology and Informatics
|September 7, 2011
PubMed
Summary

This study introduces a web-based system to help type 2 diabetes patients manage their once-daily long-acting insulin doses. The system simplifies insulin self-titration, improving blood glucose control and patient management.

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Area of Science:

  • Endocrinology
  • Diabetes Management
  • Health Informatics

Background:

  • Insulin therapy is crucial for diabetes mellitus management.
  • Effective insulin treatment necessitates regular blood glucose monitoring and dose adjustment (titration).
  • Current titration methods can be challenging for patients, particularly those with type 2 diabetes.

Purpose of the Study:

  • To present the development and design of a novel web-based decision support system for insulin self-titration.
  • To guide patients with type 2 diabetes on once-daily long-acting insulin therapy.
  • To outline the system's functionalities based on elicited patient and expert requirements.

Main Methods:

  • Literature review to identify existing practices and challenges in insulin titration.
  • Expert panel consultations to gather clinical insights and requirements.
  • Patient interviews to understand user needs and preferences for a self-titration system.
  • Iterative development of a web-based decision support system incorporating identified requirements.

Main Results:

  • Identified four key aspects for system development: insulin titration algorithm, hypoglycemia management, telemedicine features, and visit frequency monitoring.
  • Developed a fully functional web-based decision support system tailored to patient needs.
  • The system aims to empower patients in managing their insulin dosage effectively.

Conclusions:

  • The developed web-based system provides a structured approach to insulin self-titration for type 2 diabetes patients.
  • The system integrates essential features like an algorithm, hypoglycemia handling, and telemedicine support.
  • This tool has the potential to improve diabetes self-management and patient outcomes.