Drosophila as a developmental paradigm of regressive brain evolution: proof of principle in the visual system

Evolutionary developmental biology focuses heavily on the constructive evolution of body plan components, but there are many instances such as parasitism, cave adaptation, or postembryonic growth rate optimization where evolutionary regression is of adaptive value. This is particularly true in the nervous system because of its massive energy costs. However, comparatively little effort has thus far been made to understand the evolutionary developmental trajectories of adaptive nervous system reduction. This review focuses on the organization and evolution of the Drosophila larval brain, which represents an exceptional example of miniaturization, most dramatically in the visual system. It is specifically discussed how the dependency of outer optic lobe development on retinal innervation can be assumed to have facilitated a first evolutionary phase of larval visual system reduction. Afferent input-contingent development of neu- ral compartments very likely plays a widespread role in adaptive brain evolution. Understanding the complete deconstruction of the larval optic neuropiles in Drosophila awaits expanded comparative analysis but has the promise to inform about further developmental trajectories and mechanisms underlying regressive evolution of the brain.