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Related Experiment Video

Updated: May 29, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Plasma viscosity in giant cell arteritis.

Carsten Finke1, Jan Schroeter, Ulrich Kalus

  • 1Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. carsten.finke @ charite.de

European Neurology
|September 7, 2011
PubMed
Summary

Plasma viscosity (PV) may aid in diagnosing giant cell arteritis (GCA). Elevated PV levels were observed in GCA patients, offering a potential diagnostic marker for early detection, especially when diagnostic criteria are not met.

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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Area of Science:

  • Rheumatology
  • Clinical Immunology
  • Internal Medicine

Background:

  • Current diagnosis of giant cell arteritis (GCA) relies on American College of Rheumatology criteria.
  • Not all GCA patients meet these criteria, potentially delaying diagnosis and increasing complication risks.

Purpose of the Study:

  • To investigate acute phase response markers in GCA patients.
  • To identify more specific markers for GCA diagnosis, particularly in cases not meeting current criteria.

Main Methods:

  • An observational study comparing GCA and non-GCA patients.
  • Patients were matched for erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels.
  • Analysis focused on plasma viscosity (PV) as an acute phase response marker.

Main Results:

  • Plasma viscosity (PV) was significantly elevated in all GCA patients.
  • PV levels were normal in non-GCA patients.
  • PV demonstrated a significant difference between GCA and non-GCA cohorts.

Conclusions:

  • Plasma viscosity (PV) may represent a more specific indicator of acute inflammation in GCA.
  • PV analysis could enhance the reliability of early GCA diagnosis.
  • PV may be particularly valuable for diagnosing suspected GCA cases that do not meet existing criteria.