Related Experiment Video
Updated: May 29, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Neurobiology of bipolar disorder - lessons from migraine disorders
1University of Cambridge School of Clinical Medicine, UK.
Abstract:
Treatment for Bipolar Affective Disorder is at present largely empirical, in the lack of a definitive understanding of the biological basis of the condition. Many theories have been proposed regarding the underlying neurobiology. These have included aetiologies relating to altered neurotrophic factor expression, mitochondrial endoplasmic reticulum dysfunction with related calcium changes, and loss of inhibitory interneurons. Here an attempt is made to integrate such current understanding, in part by considering the changes observed in migraine - a condition which has a number of similarities with bipolar disorder.
Related Concept Videos
Bipolar Disorder
Depression: Overview
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Mania and Antimanic Drugs: Overview
Introduction to Biological Bases of Psychology
The nervous system, the cornerstone of...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
