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Updated: May 29, 2026
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Extraskeletal osteosarcoma, telangiectatic variant arising from the small bowel mesentery
Muhammad I Hussain1, Mohammed H Al-Akeely, Mohammed K Alam
1Department of Surgery, King Saud University Unit, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia. ibrarme@yahoo.com
Saudi Medical Journal
|September 7, 2011
Summary
Extraskeletal osteosarcoma (EOS), a rare soft tissue tumor, can arise in the mesentery. This case highlights a 40-year-old male with mesenteric EOS presenting as gastrointestinal bleeding and liver metastasis.
Area of Science:
- Oncology
- Pathology
- Gastroenterology
Background:
- Extraskeletal osteosarcoma (EOS) is a rare, aggressive soft tissue tumor.
- EOS typically lacks bone or periosteal attachment and rarely affects visceral organs.
- Mesenteric EOS is exceptionally rare, with only three prior English literature reports.
Observation:
- A 40-year-old male presented with lower gastrointestinal bleeding.
- Imaging revealed a large mesenteric mass with liver metastasis.
- Endoscopic evaluations of the upper and lower GI tracts were unremarkable.
Findings:
- Histopathology confirmed a telangiectatic type extraskeletal osteosarcoma originating in the mesentery.
- The tumor measured approximately 13x7x7 cm and involved adjacent small bowel.
- The patient underwent palliative resection of the tumor and involved small bowel.
Implications:
- This case expands the understanding of rare mesenteric EOS presentations.
- Early diagnosis and surgical management are crucial for improving outcomes in mesenteric EOS.
- Further research is needed to establish optimal treatment protocols for this rare entity.
