Related Experiment Video
Updated: May 29, 2026

In Vivo Functional Brain Imaging Approach Based on Bioluminescent Calcium Indicator GFP-aequorin
Published on: January 8, 2016
Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin
Shuzhong He1, Hongguang Li, Yuk-Wang Yip
1Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China.
Abstract:
A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (K(B) = 6.1 × 10(4) M(-1)) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption cross-section from 9 to 36 GM.
