Efficient determination of the epidermal optical properties using a diffusion model-based approach: Monte Carlo...

Area of Science:

• Biomedical Optics
• Medical Imaging
• Tissue Optics

Background:

• Previous studies established diffusing probe geometry for in vivo skin optical property recovery using a two-layer diffusion model.
• Modification to the diffusing probe with planar source (DPPS) geometry demonstrated comparable efficiency to standard semi-infinite diffusion models for superficial tissue quantification.

Purpose of the Study:

• To evaluate the performance of the DPPS diffusion model using Monte Carlo simulations and phantom measurements.
• To compare the DPPS geometry with conventional planar source illumination for interrogating superficial sample volumes.
• To assess the capability of the DPPS geometry in recovering epidermal optical properties and detecting early-stage melanoma.

Main Methods:

• Monte Carlo simulations were employed to model light propagation and assess DPPS geometry performance.
• Phantom measurements were conducted to validate simulation results and model accuracy.
• The DPPS diffusion model was utilized to recover optical properties of superficial tissue layers.

Main Results:

• The DPPS geometry demonstrated advantages over conventional planar source illumination for superficial volume interrogation.
• DPPS geometry accurately recovered optical properties of a 50-μm thick epidermis.
• Simulations indicated the potential for detecting cutaneous melanoma as small as 250 μm in radius.

Conclusions:

• The DPPS diffusion model provides precise, real-time quantification of superficial tissue optical properties.
• The DPPS geometry is a valuable tool for non-invasive skin diagnostics, particularly for early detection of skin cancers like melanoma.