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Lactoferrin delivery systems: approaches for its more effective use.

Hiraku Onishi1

  • 1Hoshi University, Department of Drug Delivery Research, Ebara, Shinagawa-ku, Tokyo, Japan. onishi@hoshi.ac.jp

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Summary

Lactoferrin (LF) shows promise for treating refractory diseases by activating the immune system. Delivery systems like PEGylation and liposomes enhance LF stability and efficacy for oral administration.

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Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Despite advances in pharmacotherapy, many refractory diseases remain challenging.
  • Alternative medicine and health foods, like lactoferrin (LF), are gaining attention.
  • LF is a non-toxic, low-cost glycoprotein with potential for widespread healthcare applications.

Purpose of the Study:

  • To review the basic features of lactoferrin (LF).
  • To explore LF's role in immune system activation for treating refractory diseases.
  • To discuss challenges and potential solutions for LF administration.

Main Methods:

  • Review of lactoferrin's interaction with receptors and immune system activation.
  • Analysis of oral administration strategies for diseases like inflammatory bowel disease, viral infections, and tumor metastasis.
  • Evaluation of delivery systems to overcome LF degradation.

Main Results:

  • LF interaction with receptors activates immune responses, including cytokine production.
  • Oral LF administration is a potential strategy for refractory diseases.
  • LF degradation by enzymatic hydrolysis necessitates high doses or frequent administration.

Conclusions:

  • Chemical modifications (e.g., PEGylation) improve LF stability and efficacy.
  • Liposomes and enteric/microparticulate formulations enhance oral LF delivery and protection.
  • Advanced delivery systems are crucial for improving lactoferrin's therapeutic utility.