Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Stimulants01:29

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Price of Nitazenes for Sale on Cryptomarkets and Surface Web Shops.

Drug and alcohol review·2026
Same author

The Effectiveness of Parent-Targeted Digital Health Interventions on Breastfeeding Practices: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal of medical Internet research·2026
Same author

A Pilot mHealth Text Messaging Program Targeting Parents During the First 2000 Days: Nonrandomized Repeat Cross-Sectional Analysis to Evaluate Feasibility, Engagement, Acceptability, and Potential Effectiveness.

JMIR mHealth and uHealth·2026
Same author

Evaluating diagnostic criteria for compulsive buying-shopping disorder.

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors·2026
Same author

A Qualitative Study to Inform Cultural Adaptations of a Healthy Lunchbox Programme for Schools With High Aboriginal Enrolment in the Hunter New England Region of Australia.

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals·2026
Same author

Are people who use methamphetamine at increased risk of physical violence? Results from a nationally representative sample.

Addiction (Abingdon, England)·2026

Related Experiment Video

Updated: May 29, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

A systematic review of methamphetamine precursor regulations.

Rebecca McKetin1, Rachel Sutherland, David A Bright

  • 1Centre for Mental Health Research, ANU College of Medicine, Biology, and Environment, The Australian National University, Canberra, Australia. rebecca.mcketin@anu.edu.au

Addiction (Abingdon, England)
|September 8, 2011
PubMed
Summary

Methamphetamine precursor regulations effectively reduce illicit supply and use, with some interventions showing significant decreases. However, alternative sources and imported supplies can limit effectiveness, necessitating further research.

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

Published on: February 5, 2018

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Area of Science:

  • Public Health
  • Criminology
  • Pharmacology

Background:

  • Illicit methamphetamine production relies on precursor chemicals.
  • Effective regulation of these precursors is crucial for supply reduction.

Purpose of the Study:

  • To evaluate the impact of methamphetamine precursor regulations on illicit supply and use.
  • To identify factors influencing the effectiveness of these regulations.

Main Methods:

  • Systematic review of 12 databases.
  • Inclusion of studies using Effective Practice and Organization of Care (EPOC) guidelines.
  • Assessment of 15 interventions (13 regulations, 2 interdictions) in North America.

Main Results:

  • Seven of 15 interventions demonstrated reductions in methamphetamine indicators (12-77%).
  • Interdiction efforts, including shutting down rogue companies, showed significant impact.
  • No evidence of substitution to other drugs or increased injecting use was found.

Conclusions:

  • Methamphetamine precursor regulations can successfully decrease supply and use indicators.
  • Effectiveness may be limited by alternative precursor sources or imported methamphetamine.
  • Further research is needed on global applicability, impact on synthetic drugs, and improved precursor diversion data.