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Parathyroid hormone and its effects on dental tissues
1Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Oral Diseases
|September 8, 2011
Summary
Synthetic parathyroid hormone (PTH) can promote bone growth when administered intermittently, aiding in jaw bone repair and dental implant success. Continuous PTH use may lead to bone loss, highlighting the importance of administration timing.
Area of Science:
- Endocrinology
- Bone Biology
- Periodontology
Background:
- Osteoporosis management involves various pharmacological agents.
- Synthetic parathyroid hormone (PTH) is a key treatment option.
- PTH exhibits dual effects on bone, influencing both apposition and resorption based on administration timing.
Purpose of the Study:
- To review the effects of synthetic parathyroid hormone (PTH) on jaw bones (mandible and maxilla).
- To differentiate the outcomes of intermittent versus continuous PTH administration.
- To explore the role of PTH in periodontal repair and dental implant success.
Main Methods:
- Review of molecular mechanisms of PTH action.
- Analysis of experimental animal studies on PTH effects.
- Examination of human clinical data regarding PTH administration.
Main Results:
- Intermittent PTH administration, at human-tolerated doses, enhances bone strength and prevents fractures.
- Continuous PTH administration can result in bone loss.
- Intermittent PTH stimulates bone mineral content, particularly in the pre-alveolar region, benefiting periodontal repair and implant outcomes.
Conclusions:
- Intermittent PTH administration is crucial for therapeutic bone benefits, including enhanced jaw bone density.
- The timing of PTH administration significantly dictates its impact on bone metabolism.
- PTH shows promise in improving periodontal health and increasing the success rate of dental implants.
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