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Updated: May 29, 2026
07:17
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Regulatory T cell: a protection for tumour cells
Yi Wang1, Yushui Ma, Ying Fang
1The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China.
Journal of Cellular and Molecular Medicine
|September 8, 2011
Summary
Regulatory T cells (Tregs) accumulate in tumors, suppressing anti-tumor immunity and leading to poor prognosis. This review explores Treg suppressive mechanisms and immunotherapies targeting them.
Area of Science:
- Immunology
- Oncology
Background:
- Regulatory T cells (Tregs) are crucial for immune tolerance.
- High Treg density in tumor stroma correlates with worse patient prognosis.
- Tregs are implicated in inhibiting anti-tumor immune responses within the tumor microenvironment.
Purpose of the Study:
- To demonstrate the accumulation of Tregs in tumor stroma.
- To elucidate the mechanisms by which Tregs suppress anti-tumor immunity.
- To review current immunotherapies being investigated for Treg-related tumor suppression.
Main Methods:
- Review of existing literature on Treg accumulation in tumors.
- Analysis of proposed mechanisms of Treg-mediated immunosuppression.
- Survey of ongoing animal and clinical trials for immunotherapies targeting Tregs.
Main Results:
- Confirmation of significant Treg accumulation within tumor stroma.
- Identification of key suppressive mechanisms employed by tumor-infiltrating Tregs.
- Overview of various immunotherapeutic strategies under investigation.
Conclusions:
- Treg accumulation in tumor stroma contributes to immune evasion and poor prognosis.
- Understanding Treg suppressive functions is vital for developing effective cancer immunotherapies.
- Targeting Tregs holds promise for enhancing anti-tumor immunity in clinical settings.
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