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Related Experiment Video

Updated: May 29, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

Abiotrophia defectiva knee prosthesis infection: A case report.

Nadim Cassir1, Jean-Charles Grillo, Jean-Noël Argenson

  • 1Pôle des Maladies Infectieuses et Tropicales, Assistance Publique - Hôpitaux de Marseille et Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR 6236, IRD 198, IFR48, Université de la Méditerranée, Marseille, France. michel.drancourt@univmed.fr.

Journal of Medical Case Reports
|September 8, 2011
PubMed
Summary

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Abiotrophia defectiva, a rare cause of bone infections, can be missed by standard tests. Advanced culturing and PCR of synovial fluid are crucial for diagnosing these difficult Abiotrophia orthopedic infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Orthopedic Surgery

Background:

  • Abiotrophia species are infrequently associated with osteoarticular infections.
  • This case highlights a knee prosthesis infection caused by Abiotrophia defectiva.

Purpose of the Study:

  • To report a case of Abiotrophia defectiva knee prosthesis infection.
  • To emphasize diagnostic challenges and effective treatment strategies for rare microbial infections in orthopedic implants.

Main Methods:

  • A patient with a knee prosthesis presented with infection symptoms.
  • Synovial fluid analysis using standard cultures was negative.
  • Direct inoculation into rich culture medium and PCR sequencing identified Abiotrophia defectiva.

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Main Results:

  • Standard synovial fluid cultures failed to detect the causative agent.
  • Polymerase chain reaction sequencing confirmed Abiotrophia defectiva.
  • The patient recovered after a nine-month antibiotic course and prosthesis replacement.

Conclusions:

  • Abiotrophia species are fastidious and often lead to misdiagnosis as culture-negative infections.
  • Direct inoculation into rich broth and PCR are vital for detecting these infections.
  • Accurate diagnosis is essential for effective management of Abiotrophia orthopedic infections.