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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...

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Updated: May 29, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

[Vitamin D in the elderly: 5 points to remember].

Cédric Annweiler1, Jean-Claude Souberbielle, Anne-Marie Schott

  • 1Département de médecine interne et gériatrie, Centre hospitalier universitaire d'Angers, France. CeAnnweiler@chu-angers.fr

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|September 8, 2011
PubMed
Summary

Vitamin D deficiency (hypovitaminosis D) affects 85% of the elderly, increasing chronic disease and frailty risks. Supplementation with vitamin D3 can improve health outcomes and reduce mortality.

Related Experiment Videos

Last Updated: May 29, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Endocrinology
  • Nutritional Science

Context:

  • Vitamin D is a crucial secosteroid hormone with widespread receptor presence.
  • Hypovitaminosis D is linked to numerous health issues, affecting target tissue function.
  • The optimal serum 25-hydroxyvitamin D level to prevent adverse health events is approximately 30 ng/mL.

Purpose:

  • To highlight the prevalence and consequences of vitamin D deficiency.
  • To emphasize the role of vitamin D supplementation in mitigating health risks.

Summary:

  • 85% of elderly individuals do not meet the target serum 25-hydroxyvitamin D concentration of 30 ng/mL without supplementation.
  • Hypovitaminosis D serves as a biomarker for chronic diseases and frailty in this population.
  • Vitamin D supplementation positively influences bone and non-bone health, including reducing fall and fracture risks.

Impact:

  • Correcting vitamin D deficiency can significantly improve bone health and reduce non-bone morbidities.
  • Supplementation with 800-1,000 IU of vitamin D3 daily is recommended for maintaining adequate levels.
  • Addressing hypovitaminosis D can lead to a reduced mortality rate and improved overall health in the elderly.