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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...

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Updated: May 29, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

A quality index for equivalent uniform dose.

Francisco Cutanda Henríquez¹, Silvia Vargas Castrillón

¹Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Journal of Medical Physics

|September 8, 2011

Summary

Equivalent uniform dose (EUD) assumes homogeneous and non-homogeneous irradiations are equivalent. This study reveals their clonogen survival distributions differ, impacting EUD

Area of Science:

Radiation Oncology
Medical Physics
Radiobiology

Background:

Equivalent Uniform Dose (EUD) is a metric for comparing radiation therapy plans.
It assumes equivalent biological effect based on mean absorbed dose.

Purpose of the Study:

To investigate the validity of the EUD assumption.
To assess the impact of non-homogeneous irradiation on clonogen survival distributions.

Main Methods:

Mathematical analysis of clonogen survival distributions.
Derivation of a figure of merit for EUD applicability.

Main Results:

Clonogen survival distributions differ between homogeneous and non-homogeneous irradiations, even with equal mean doses.

Keywords:

Equivalent uniform dose mixed Poisson distribution radiobiology

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Published on: May 9, 2014

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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The figure of merit indicates less validity of the EUD assumption with increased dose heterogeneity.

EUD accuracy is sensitive to radiobiological parameters (e.g., alpha values).

Conclusions:

The assumption of equivalence in EUD may not always hold.
The accuracy of radiobiological indices derived from EUD can be affected by dose heterogeneity.
Careful consideration of radiobiological parameters is crucial when using EUD.