In vitro function of random donor platelets stored for 7 days in composol platelet additive solution

Area of Science:

• Transfusion Medicine
• Hematology
• Blood Banking

Background:

• Platelets are typically stored for 5 days in plasma.
• Current storage methods limit platelet inventory.
• Extending platelet shelf life is crucial for transfusion services.

Purpose of the Study:

• To evaluate the in vitro function of random donor platelets stored for 7 days.
• To assess the efficacy of platelet additive solution (Composol) for extended storage.
• To determine optimal storage conditions for random donor platelets.

Main Methods:

• 30 blood donors provided whole blood collected in CPDA-1 bags.
• Random donor platelets were prepared using the platelet-rich plasma method.
• Platelets were stored for 7 days at 22°C with and without additive solution, with agitation.

Main Results:

• Platelet swirling was observed on day 7 with no bacterial contamination.
• Platelet count, lactate dehydrogenase, and pH showed no significant difference with additive solution.
• Platelet factor 3, glucose, and aggregation were significantly better maintained with additive solution.

Conclusions:

• Platelet viability and aggregation are best maintained for 7 days in additive solution at 22°C.
• Extended storage of platelets in additive solution is a viable option.
• This approach can enhance the overall inventory of available platelets.