Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired Interoception in a Preclinical Model of Functional Dyspepsia.

Digestive diseases and sciences·2017
Same author

Pathogenesis of abdominal pain in bowel obstruction: role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells.

Pain·2017
Same author

Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats.

American journal of physiology. Gastrointestinal and liver physiology·2016
Same author

Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation.

American journal of physiology. Regulatory, integrative and comparative physiology·2015
Same author

Symptom Generation by Mucosal Inflammation in Irritable Bowel Syndrome.

Gastroenterology·2015
Same author

Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation.

American journal of physiology. Regulatory, integrative and comparative physiology·2014
Same journal

Physiological load and breath-holding in artistic swimming: a scoping review establishing historical baselines and evidence gaps in the context of the 2022-2025 rule changes.

Frontiers in physiology·2026
Same journal

Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.

Frontiers in physiology·2026
Same journal

Effects of resistance-type and cycling-type high-intensity interval training on cardiorespiratory fitness, lower-body strength, and anaerobic fitness.

Frontiers in physiology·2026
Same journal

Model-based estimates of sex differences in peak power and fatigue index in track cyclists using directed acyclic graphs, inverse probability of treatment weighting, and Bayesian modeling.

Frontiers in physiology·2026
Same journal

Fine-tuning striated muscle performance: conserved sarcomere-level mechanisms across insect and vertebrate systems.

Frontiers in physiology·2026
Same journal

Effects of different dual-task trainings on gait and cortical activation during obstacle crossing in stroke patients: a randomized controlled trial.

Frontiers in physiology·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Lessons Learnt from Post-Infectious IBS.

Sushil K Sarna1

  • 1Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston Galveston, TX, USA.

Frontiers in Physiology
|September 8, 2011
PubMed
Summary
This summary is machine-generated.

Mild mucosal inflammation may not cause Irritable Bowel Syndrome (IBS) symptoms. This review explores potential molecular dysfunctions in gut motility and visceral sensitivity, questioning the focus on inflammation.

Keywords:
enteric neuronsepithelial permeabilityfunctional bowel disordersgut inflammationimmune cellsinflammatory bowel diseasesmooth musclevisceral pain

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
04:05

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

Related Experiment Videos

Last Updated: May 29, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
04:05

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

Area of Science:

  • Gastroenterology
  • Immunology
  • Neuroscience

Background:

  • Irritable Bowel Syndrome (IBS) symptoms, including altered bowel function and abdominal cramping, can follow severe enteric infections.
  • Previous research focused on persistent mild mucosal inflammation as a cause of IBS, even in non-infectious cases.

Purpose of the Study:

  • To critically evaluate the prevailing hypothesis that mild mucosal inflammation causes IBS.
  • To explore alternative mechanisms involving smooth muscle cells, myenteric neurons, and primary afferent neurons in IBS pathogenesis.

Main Methods:

  • Review of existing studies on mucosal inflammation in IBS patients.
  • Analysis of data on immune cell infiltration, inflammatory mediators, and epithelial permeability.
  • Examination of the roles of circular smooth muscle cells, myenteric neurons, and afferent neurons in gut function.

Main Results:

  • Inconsistent findings exist regarding mucosal inflammation in IBS.
  • Treatments targeting inflammation (prednisone, fluoxetine, ketotifen) have largely failed to relieve IBS symptoms.
  • Mild mucosal inflammation in IBS is often within physiological ranges and unlikely to directly cause distant cellular dysfunction.

Conclusions:

  • The link between mild mucosal inflammation and IBS symptoms is questionable.
  • Dysfunctions in smooth muscle cells, myenteric neurons, and primary afferent neurons are more plausible explanations for IBS.
  • Future research should investigate these neural and muscular mechanisms.