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Related Experiment Video

Updated: May 29, 2026

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

Concise review: Anemia caused by viruses.

Frédéric Morinet¹, Marianne Leruez-Ville, Sylvie Pillet

¹Centre des Innovations Thérapeutiques en Oncologie et Hématologie, CHU Saint-Louis, Paris, France. frederic.morinet@sls.aphp.fr

Stem Cells (Dayton, Ohio)

|September 8, 2011

Summary

This summary is machine-generated.

Viruses can cause anemia by directly harming blood cells or through immune responses. Host genetics may also influence susceptibility to virus-induced anemia.

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Area of Science:

Hematology
Virology
Immunology

Background:

Anemia is linked to persistent, non-cytopathic viral infections in humans.
Viruses implicated include Epstein-Barr virus, cytomegalovirus, HHV-6, parvovirus B19, HIV, and hepatitis viruses.
Direct viral cytotoxicity on erythroid progenitors is established for parvovirus B19 and suggested for HHV-6.

Purpose of the Study:

To review viral associations with anemia.
To explore mechanisms of virus-induced anemia, including direct cytotoxicity and immune-mediated damage.
To consider the role of host genetics in virus-associated anemia.

Main Methods:

Literature review of viral infections associated with anemia.
Analysis of reported mechanisms of anemia pathogenesis.
Examination of evidence for genetic influences on virus-induced anemia.

Main Results:

Direct cytotoxic effects on erythroid progenitors are confirmed for human parvovirus B19 and suggested for human herpes virus 6 (HHV-6).
Destructive immunity is strongly suspected as a major pathogenic mechanism for other viral infections causing anemia.
Host genes influence virus-induced anemia in animal models, with evidence suggesting a similar role in humans.

Conclusions:

Viral infections can lead to anemia through direct cell damage or immune responses.
Human parvovirus B19 and HHV-6 show direct cytotoxic effects on erythroid progenitors.
Host genetic factors likely play a role in the development of virus-associated anemia in humans.