Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage.

The New England journal of medicine·2026
Same author

Platelet function assays fail to detect differences between transfusion of cold or room temperature platelets in traumatic brain injury patients.

The journal of trauma and acute care surgery·2026
Same author

Severe Pediatric Traumatic Brain Injury Presenting Characteristics: Abusive Versus Accidental Trauma.

Journal of neurotrauma·2025
Same author

Pragmatic Early Predictors of Survival After Trauma.

The Journal of surgical research·2025
Same author

Bright Light Therapy in the Morning or Midday for the Treatment of Nonseasonal Depression in Bipolar Disorder (LuBi): A Dose-Escalation Phase 1/2 Randomized Double-Blind Trial.

The Journal of clinical psychiatry·2025
Same author

Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy.

The journal of trauma and acute care surgery·2025
Same journal

Systematic Review and Exploratory Meta-Analysis of AI-Enabled and Digital Technology-Assisted Interventions for Dental Anxiety During Dental Treatment.

Depression and anxiety·2026
Same journal

Measurement of Serum Parameters Attributes the Therapeutic Effects of Music Therapy to Augmented Stress-Coping Ability and Diminished Systemic Inflammation.

Depression and anxiety·2026
Same journal

Differential Patterns of Social Attention and Memory Profiles in Depression: Evidence From Third-Person Social Interaction Processing.

Depression and anxiety·2026
Same journal

Associations Between Adverse Childhood Experiences and Prenatal Depression Mediated Through Family Communication in Chinese Pregnant Women: Causal Mediation Analysis.

Depression and anxiety·2026
Same journal

How Does Fertility Stress Influence Depressive Symptoms in Female Partners of Infertile Couples in China? A Parallel Mediation Analysis of Infertility Stigma and Family Function.

Depression and anxiety·2026
Same journal

Network and Factor Structure of Depression and Anxiety Symptoms in Telemental Healthcare Patients From Bangladesh: Evidence for Precision Mental Healthcare.

Depression and anxiety·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Depression treatment and maternal functioning.

M Cynthia Logsdon1, Katherine Wisner, Dorothy Sit

  • 1University of Louisville, Nursing, Louisville, Kentucky 40202, USA. mclogs01@gwise.louisville.edu

Depression and Anxiety
|September 8, 2011
PubMed
Summary
This summary is machine-generated.

Treatment for major depressive disorder (MDD) in mothers improves maternal functioning. Women responding to serotonin selective reuptake inhibitors (SSRIs) showed similar functioning to controls, outperforming untreated or non-responding individuals.

More Related Videos

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
06:40

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period

Published on: April 5, 2024

Related Experiment Videos

Last Updated: May 29, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
06:40

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period

Published on: April 5, 2024

Area of Science:

  • Psychiatry
  • Reproductive Health
  • Mental Health

Background:

  • Major depressive disorder (MDD) significantly impairs maternal role functioning in women.
  • Existing research often lacks control groups and longitudinal data on treatment effects.
  • Serotonin selective reuptake inhibitors (SSRIs) are a common treatment for MDD.

Purpose of the Study:

  • To investigate the impact of SSRI treatment response on maternal role functioning in women with MDD.
  • To compare functioning in SSRI responders to control groups and non-responders.
  • To evaluate overall and maternal-specific functioning longitudinally.

Main Methods:

  • Prospective, longitudinal observational study with 215 postpartum women.
  • Categorization into four groups: Control, SSRI Responder, Untreated MDD, and SSRI Nonresponder.
  • Assessment of overall functioning (Global Assessment Scale, GAS) and maternal role functioning (Maternal Self Efficacy, Gratification in Maternal Role, IFSAC) at multiple postpartum time points.

Main Results:

  • The study hypothesis was supported, confirming improved functioning with SSRI treatment.
  • SSRI responders demonstrated overall and maternal role functioning scores comparable to the control group.
  • Responders' functioning significantly surpassed that of untreated and non-responding women with MDD, as evidenced by GAS and GRAT scores.

Conclusions:

  • Effective postpartum depression treatment should aim for both symptom remission and restoration of maternal role functioning.
  • The Gratification in Maternal Role (GRAT) scale is a practical tool for assessing maternal role functioning alongside depression measures.