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Updated: May 29, 2026

Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
Published on: May 15, 2015
Feasibility of ultra high performance supercritical neat carbon dioxide chromatography at conventional pressures
Cédric Sarazin1, Didier Thiébaut, Patrick Sassiat
1CNRS UMR 7195 PECSA, Laboratoire Sciences Analytiques, Bioanalytiques et Miniaturisation, ESPCI ParisTech, Paris, France.
Abstract:
The implementation of columns packed with sub-2 μm particles in supercritical fluid chromatography (SFC) is described using neat carbon dioxide as the mobile phase. A conventional supercritical fluid chromatograph was slightly modified to reduce extra column band broadening. Performances of a column packed with 1.8 μm C18-bonded silica particles in SFC using neat carbon dioxide as the mobile phase were compared with results obtained in ultra high performance liquid chromatography (UHPLC) using a dedicated chromatograph. As expected and usual in SFC, higher linear velocities than in UHPLC must be applied in order to reach optimal efficiency owing to higher diffusion coefficient of solutes in the mobile phase; similar numbers of theoretical plates were obtained with both techniques. Very fast separations of hydrocarbons are presented using two different alkyl-bonded silica columns.
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