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Related Experiment Videos

Cutaneous nickel sensitivity in Toronto, Canada.

J R Nethercott1, D L Holness

  • 1Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205-2179.

Journal of the American Academy of Dermatology
|May 1, 1990
PubMed
Summary

Nickel allergy is common, especially in women, with patch tests confirming reactions in over 10% of subjects. Most reactions were linked to domestic exposure and indicated a lower irritancy threshold for some substances.

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Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Contact dermatitis is a common skin condition.
  • Nickel allergy is a frequent cause of allergic contact dermatitis.

Purpose of the Study:

  • To evaluate the prevalence and relevance of nickel allergy in subjects with suspected contact dermatitis.
  • To investigate potential links between nickel sensitivity and reactions to other substances.

Main Methods:

  • Patch testing was performed on 1074 subjects using nickel sulfate in petrolatum.
  • Clinical findings were correlated with patch test results in 447 subjects.

Main Results:

  • 10.5% of subjects tested with 5% nickel sulfate and 11.9% tested with 2.5% nickel sulfate showed positive reactions.

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  • Over 90% of positive patch test responses were clinically relevant to contact dermatitis.
  • Nickel-sensitive individuals showed increased reactivity to irritants like formaldehyde and benzoyl peroxide.
  • Domestic exposure was the primary suspected source of nickel allergy induction.

    • Conclusions:

    • Nickel allergy is prevalent, particularly in females, and patch testing is a relevant diagnostic tool.
    • Nickel sensitivity may lower the threshold for irritant reactions.
    • Domestic exposure is a significant factor in the development of nickel allergy.