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Updated: May 29, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Off-pump coronary artery bypass grafting with large cerebral infarction; report of a case]
Noriyoshi Yashiki1, Hiroshi Saito, Masahiro Oshima
1Department of Thoracic Surgery, Koseiren Takaoka Hospital, Takaoka, Japan.
Insights
Off-pump coronary artery bypass grafting (OPCAB) is a viable option for patients with acute myocardial infarction and a history of large, chronic cerebral infarction. This surgical approach can be safely performed without worsening neurological deficits.
Area of Science:
- Cardiology
- Neurology
- Cardiothoracic Surgery
Background:
- A 48-year-old male presented with acute myocardial infarction (AMI).
- The patient had a significant past medical history of cerebral infarction 26 years prior, resulting in left hemiparesis.
- Coronary angiography identified left main trunk and multi-vessel disease, unsuitable for catheter intervention.
Observation:
- Brain computed tomography (CT) revealed a large right-sided cerebral infarction.
- The patient underwent off-pump coronary artery bypass grafting (OPCAB) for his cardiac condition.
- Postoperatively, the patient's pre-existing hemiparesis did not progress.
Findings:
- Off-pump coronary artery bypass grafting (OPCAB) was successfully performed in a patient with acute myocardial infarction and extensive chronic cerebral infarction.
- The surgical procedure did not lead to any exacerbation of the patient's neurological deficits.
Implications:
- OPCAB may be a safe and effective revascularization strategy for patients with acute coronary syndromes and chronic, stable cerebral infarctions.
- This approach could be considered even in cases of large cerebral infarcts, provided neurological function is preserved.
- Careful patient selection and surgical technique are crucial when considering OPCAB in patients with comorbid cerebrovascular disease.
Abstract:
A 48-year-old male was consulted to our hospital on the next day when he was developed acute myocardial infarction (AMI). He developed cerebral infarction 26 years ago, and had left hemiparesis. Coronary angiogram revealed left main trunk and 2 vessels disease which was not amenable to catheter intervention, and brain computed tomography (CT) showed a very large infarction in right cerebrum. Off-pump coronary artery bypass grafting (OPCAB) double bypass grafting was performed. The paralysis did not get worse in the post operative course. He was discharged to his home. If the cerebral infarction is chronic phase with preserved neurological function, OPCAB may be recommended, even if it is large infarction.
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