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Retinal periphlebitis in patients with multiple sclerosis

Miroslav Stamenković1, Dragana Obradović

  • 1University Medical Center Zvezdara, Eye Clinic, Belgrade, Serbia. drmiroslavstamenkovic@gmail.com

Vojnosanitetski Pregled
|September 9, 2011
PubMed
Abstract

Insights

Retinal periphlebitis (RP) is more common in progressive multiple sclerosis (MS) and indicates increased disease activity. Its presence correlates with blood-brain barrier impairment and may help monitor MS progression and treatment effectiveness.

Area of Science:

  • Neuroimmunology
  • Ophthalmology
  • Neurology

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) disorder involving inflammation, demyelination, and axonal loss.
  • Retinal periphlebitis (RP) shares histopathological similarities with MS lesions and is frequently observed in MS patients.

Purpose of the Study:

  • To investigate the occurrence of RP in MS patients across different clinical phases.
  • To determine the association between RP and blood-brain barrier (BBB) dysfunction in MS.

Main Methods:

  • Study included 45 MS patients (26 female, 19 male) with varying MS subtypes (RR, PP, SP) and disease phases (relapse, remission).
  • Evaluations included ophthalmological, neurological, and MRI examinations, cerebrospinal fluid analysis, and calculation of albumin ratio and IgG index.

Main Results:

  • RP was present in 9 patients, predominantly in those with longer MS duration and progressive forms.
  • Patients with RP showed elevated albumin ratio and IgG index, indicating increased BBB permeability.
  • Higher visual evoked potential (VEP) latency was observed in the RP group, suggesting neurological impact.

Conclusions:

  • Retinal periphlebitis (RP) serves as a reliable indicator of active multiple sclerosis (MS).
  • RP can be utilized as a parameter for monitoring MS disease activity and treatment efficacy.

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