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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Group A streptococcal cellulitis in the early puerperium
Branka Nikolić1, Ana Mitrović, Svetlana Dragojević-Dikić
1University of Belgrade, School of Medicine, Obstetrics and Gynecology Clinic "Narodni front", Belgrade, Serbia. bolnicanf@sbb.rs
Insights
Group A Streptococcus (GAS) infections can be life-threatening postpartum. Early recognition and treatment of GAS cellulitis in puerperium are crucial to prevent severe outcomes like streptococcal toxic shock syndrome (STSS).
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Obstetrics & Gynecology
Background:
- Group A Streptococcus (GAS) infections pose significant life-threatening risks, with cellulitis being a common and severe invasive presentation.
- Postpartum GAS infections, particularly streptococcal toxic shock syndrome (STSS), are often underrecognized in early puerperium.
- Limited general knowledge and awareness contribute to diagnostic challenges in postpartum GAS infections.
Observation:
- A 32-year-old woman developed GAS cellulitis three days postpartum, presenting with fever and leg pain.
- Group A Streptococcus pyogenes was identified in vaginal cultures.
- Prompt antibiotic and supportive treatment were initiated, preventing STSS and multiorganic failure.
Findings:
- The patient's infection, identified as GAS cellulitis, required 25 days for symptom resolution and nearly 50 days for complete recovery.
- Early intervention successfully halted the progression to streptococcal toxic shock syndrome (STSS).
Implications:
- Vaginal and cervical cultures are essential for all postpartum women with early-onset fever.
- Prompt diagnosis and management of GAS infections in the puerperium can prevent STSS and reduce mortality.
- Increased awareness and knowledge of postpartum GAS infections are vital for timely and effective patient care.
Introduction:
Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS) are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerperium. However, there are two main problems with GAS infection in early puerperium and this case report is aimed at reminding on them. The first problem is an absence of awareness that it can be postpartal invasive GAS infection before the microbiology laboratory confirms it, and the second one is that we have little knowledge about GAS infection, in general.
Case Report:
A 32-year-old healthy woman, gravida 1, para 1, was hospitalized three days after vaginal delivery with a 38-hour history of fever, pain in the left leg (under the knee), and head injury after short period of conscious lost. Clinical picture of GAS infection was cellulites. Group A Streptoccocus pyogenes was isolated in vaginal culture. Rapid antibiotic and supportive treatment stopped development of streptococcal toxic shock syndrome (STSS) and potential multiorganic failure. Signs and symptoms of the infection lasted 25 days, and complete recovery of the patient almost 50 days.
Conclusion:
In all women in childbed with a history of fever early after delivery, vaginal and cervical culture specimens should be taken as soon as possible. Early recognition of GAS infection in early puerperium and prompt initiation of antimicrobial drug and supportive therapy can prevent development of STSS and lethal outcome.
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