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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

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Related Experiment Video

Updated: May 29, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

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Published on: August 22, 2022

Skeletal maturation evaluation using mandibular second molar calcification stages.

Sushil Kumar1, Anu Singla, Rekha Sharma

  • 1Department of Orthodontics, PDM Dental College and Research Institute, Sarai Aurangabad, Bahadurgarh, Haryana, India. docshilu@yahoo.com

The Angle Orthodontist
|September 9, 2011
PubMed
Summary

Dental maturity stages of the mandibular second molar, assessed using the Demirjian Index (DI), strongly correlate with skeletal maturity indicators (CVMI). This indicates that DI stages reliably predict skeletal maturity in adolescents.

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Area of Science:

  • Orthodontics
  • Dental Anthropology
  • Human Growth and Development

Background:

  • Skeletal maturity assessment is crucial for orthodontic treatment planning.
  • Cervical vertebrae maturation indicators (CVMI) are commonly used to assess skeletal maturity.
  • Dental development, specifically the Demirjian Index (DI) for mandibular second molars, has been explored as a potential indicator of growth.

Purpose of the Study:

  • To examine the relationship between mandibular second molar calcification stages and skeletal maturity.
  • To evaluate the reliability of second molar calcification stages as a diagnostic tool for determining skeletal maturity.

Main Methods:

  • Analysis of panoramic radiographs and lateral cephalograms from 300 subjects (9-18 years old).
  • Assessment of dental maturity using the Demirjian Index (DI).
  • Assessment of skeletal maturity using cervical vertebrae maturation indicators (CVMI).

Main Results:

  • A significant association was observed between DI and CVMI in both males (C* = 0.854) and females (C* = 0.866).
  • Specific DI stages (E, F, G, H) were correlated with distinct CVMI stages representing pre-peak, peak, and post-peak pubertal growth.
  • Mandibular second molar calcification stages demonstrate a strong predictive capability for skeletal maturation phases.

Conclusions:

  • A strong correlation exists between the Demirjian Index (DI) for mandibular second molars and cervical vertebrae maturation indicators (CVMI).
  • Mandibular second molar DI stages serve as reliable indicators for assessing skeletal maturity in adolescents.