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Sesamol as a potential radioprotective agent: in vitro studies
K Mishra1, P S Srivastava, N K Chaudhury
1Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Radiation Research
|September 9, 2011
Summary
Sesamol, a natural antioxidant, offers superior protection against radiation-induced DNA damage compared to melatonin. This study highlights sesamol
Area of Science:
- Biochemistry
- Radiation Biology
- Molecular Biology
Background:
- Radiation-induced DNA strand breaks necessitate effective radioprotectors.
- Natural antioxidants are explored for their radioprotective potential.
- Melatonin serves as a benchmark antioxidant radioprotector.
Purpose of the Study:
- To evaluate the radioprotective efficacy of sesamol compared to melatonin.
- To investigate the radical scavenging capacity of sesamol.
- To explore sesamol's potential as a novel radioprotector.
Main Methods:
- Plasmid DNA (pBR322) and calf thymus DNA irradiation assays.
- Thermal denaturation studies.
- Radical scavenging assays: 2-deoxyribose degradation, DPPH, and ABTS.
- In vitro V79 cell studies.
Main Results:
- Sesamol demonstrated superior radioprotective efficacy against DNA strand breaks in both plasmid and calf thymus DNA.
- Sesamol exhibited significantly higher radical scavenging capacity than melatonin.
- In vitro studies indicated sesamol is 20 times more potent than melatonin in protecting V79 cells.
Conclusions:
- Sesamol possesses greater radioprotective efficacy than melatonin.
- Enhanced free radical scavenging capacity likely contributes to sesamol's superior radioprotection.
- Sesamol shows promise for development as a potent radioprotector.
