Antithrombotic lipids from Semen Persicae.

Area of Science:

• Phytochemistry
• Pharmacology

Background:

• Semen Persicae is a traditional medicinal plant.
• Understanding its chemical constituents and biological activities is crucial.

Purpose of the Study:

• To isolate and identify chemical compounds from Semen Persicae.
• To evaluate the anticoagulative properties of the isolated compounds and extracts.

Main Methods:

• Chemical analysis and extensive spectral analysis were used for structure elucidation.
• In vitro assays were performed to assess anticoagulative activities, including thrombin time prolongation and platelet aggregation inhibition.

Main Results:

• Seven compounds were isolated: decane, triolein, nonacosanoic acid, oleic acid ethyl ester, palmitic acid, oleic acid, and a new lipid (compound 7).
• Petroleum ether extract and palmitic acid (5) and oleic acid (6) significantly prolonged thrombin time.
• Methanol extract notably inhibited platelet aggregation.

Conclusions:

• Semen Persicae contains diverse chemical compounds, including a novel lipid.
• The plant extracts and specific fatty acids exhibit promising anticoagulative and antiplatelet activities, warranting further investigation.