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KIOM-79 inhibits aldose reductase activity and cataractogenesis in Zucker diabetic fatty rats

Junghyun Kim1, Chan-Sik Kim, Eunjin Sohn

  • 1Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, South Korea.

The Journal of Pharmacy and Pharmacology
|September 9, 2011
PubMed
Abstract

Insights

KIOM-79, a herbal remedy, effectively prevents diabetic cataracts by inhibiting aldose reductase activity and protein expression in the eye lens. This finding suggests KIOM-79 as a potential treatment for diabetic cataractogenesis.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic complications include nephropathy, retinopathy, and cataractogenesis.
  • Aldose reductase (AR) plays a key role in diabetic cataract development.
  • KIOM-79 is a herbal combination with known preventive effects on other diabetic complications.

Purpose of the Study:

  • To investigate the inhibitory effects of KIOM-79 on diabetic cataractogenesis.
  • To evaluate the impact of KIOM-79 on aldose reductase activity in diabetic lenses.

Main Methods:

  • Zucker diabetic fatty (ZDF) rats, a model for type 2 diabetes, were used.
  • Rats were orally administered KIOM-79 (50 mg/kg) daily for 13 weeks.
  • Aldose reductase activity and protein expression were assessed in lens tissues.

Main Results:

  • Diabetic rats exhibited increased lens opacity, swelling, and membrane rupture.
  • Aldose reductase activity and protein expression were significantly elevated in diabetic lenses.
  • KIOM-79 administration suppressed cataract development by inhibiting aldose reductase activity and expression.

Conclusions:

  • KIOM-79 demonstrates a therapeutic potential against diabetic cataractogenesis.
  • Inhibition of aldose reductase is a key mechanism for KIOM-79's anti-cataract effect.
  • KIOM-79 may be a valuable treatment option for diabetic cataracts.

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