Hidden immunotherapy targets challenge dogma

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Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Soldano Ferrone1

  • 1University of Pittsburgh Cancer Institute, PA 15213, USA. ferrones@upmc.edu

Science Translational Medicine
|September 9, 2011
PubMed

In this issue of Science Translational Medicine, Guo et al. discuss the intriguing possibility that intracellular tumor antigen-specific monoclonal antibodies (mAbs) inhibit tumor growth and metastasis and prolong survival of tumor-bearing mice. Here, I discuss the implications of using intracellular targets in mAb-based immunotherapy as well as the possible underlying mechanisms of action.

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