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Advanced glycation end product level, diabetes, and accelerated cognitive aging
Kristine Yaffe1, K Lindquist, A V Schwartz
1Department of Psychiatry, University of California, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu
Neurology
|September 9, 2011
Summary
High levels of advanced glycation end products (AGEs) are linked to faster cognitive decline in older adults. This association holds true for individuals with and without diabetes, indicating AGEs
Area of Science:
- Gerontology
- Neuroscience
- Endocrinology
Background:
- Diabetes mellitus is a known risk factor for cognitive impairment.
- Advanced glycation end products (AGEs) are hypothesized to mediate the link between diabetes and cognitive decline.
- Peripheral AGE concentration and its association with cognitive aging remain understudied.
Purpose of the Study:
- To investigate the association between peripheral AGE concentration and cognitive decline in older adults.
- To determine if this association differs between individuals with and without diabetes.
Main Methods:
- Prospective study of 920 elders (495 with diabetes, 425 normal glucose), mean age 74.0 years.
- Urine pentosidine (a marker of AGEs) measured at baseline and analyzed by tertile.
- Cognitive performance assessed using the Modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST) over 9 years.
Main Results:
- Higher baseline pentosidine levels correlated with worse Digit Symbol Substitution Test (DSST) scores.
- Individuals in the high and mid pentosidine tertiles exhibited a more pronounced 9-year decline in both 3MS and DSST scores compared to the lowest tertile.
- Increased odds of incident cognitive impairment were observed in those with high or mid pentosidine levels for both 3MS and DSST.
Conclusions:
- Elevated peripheral AGE levels are significantly associated with accelerated cognitive decline in older adults.
- This association is present irrespective of diabetes status.
- Peripheral AGEs represent a potential biomarker for cognitive aging and impairment.
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